Anti-SERCA1 Antibody

This rabbit polyclonal antibody from Antibodies.com targets SERCA1, the fast-twitch skeletal muscle isoform of the sarco/endoplasmic reticulum Ca²⁺-ATPase encoded by ATP2A1. The unconjugated reagent is supplied as 100 µl of antiserum validated for western blot, immunohistochemistry, and ELISA workflows, with reactivity confirmed against human, mouse, and rat samples. SERCA1 mediates Ca²⁺ sequestration into the sarcoplasmic reticulum, coupling ATP hydrolysis to active calcium transport during muscle relaxation. Researchers investigating excitation-contraction coupling, Brody myopathy, or calcium-handling defects in skeletal muscle use this reagent to detect endogenous SERCA1 protein in tissue lysates and fixed sections. The polyclonal host response yields recognition of multiple epitopes across the target, supporting consistent signal in heterologous expression systems and in vivo muscle preparations.