Anti-SENP5 Antibody

SENP5 (Sentrin/SUMO-specific protease 5) is a SUMO-specific cysteine protease that localizes predominantly to mitochondria, where it contributes to mitochondrial dynamics, fission, and the maturation of mitochondrial SUMO conjugates. This polyclonal antibody, raised in rabbit and supplied by Antibodies.com as a 100 µl vial of unconjugated antisera, recognizes endogenous SENP5 in human and mouse samples.

Validated applications include Western blot (WB) for detection of SENP5 across cell line and tissue lysates, and immunohistochemistry (IHC) for visualizing SENP5 distribution in fixed tissue sections. Researchers working on SUMOylation pathways, mitochondrial morphology, apoptosis regulation, ribosome biogenesis at mitochondria, and the post-translational control of mitochondrial proteins in cancer and neurodegeneration models will find this reagent relevant to their workflow.

The polyclonal format offers broader epitope coverage for tracking full-length SENP5 and potential isoforms, while the unconjugated presentation allows flexible pairing with HRP, biotin, or fluorophore-conjugated secondary reagents of the user's choice. For handling, aliquot on arrival to limit freeze-thaw cycles and store refrigerated for short-term use, reserving frozen stocks for long-term storage.