Anti-SENP3 Antibody

This rabbit polyclonal primary antibody from Antibodies.com targets SENP3 (Sentrin-specific protease 3), a SUMO2/3-specific cysteine protease localized primarily to the nucleolus. The unconjugated reagent is supplied as a 100 µl aliquot and is validated for Western blot (WB) and immunohistochemistry (IHC) workflows. Reactivity has been confirmed in human and mouse samples, supporting cross-species studies in cell lysates and formalin-fixed tissue sections.

SENP3 catalyzes the deconjugation of SUMO2/3 modifications from substrate proteins and participates in 40S ribosomal subunit maturation, oxidative stress signaling, and hypoxia-driven HIF-1α accumulation. Investigators apply this antibody to examine SENP3 expression in cancer models, neurodegeneration research, and stress-response pathways. The polyclonal format recognizes multiple epitopes across the SENP3 protein, enhancing signal robustness on denatured western blot membranes and antigen-retrieved IHC preparations, and the antibody is recommended for research use only.