Anti-Secretin Receptor Antibody

This rabbit polyclonal reagent from Antibodies.com targets the human Secretin Receptor (SCTR), a class B G protein-coupled receptor that couples secretin binding to adenylate cyclase activation and intracellular cAMP elevation. Supplied as an unconjugated liquid in a 100 µl vial, the antibody has been validated for western blot analysis of cell and tissue lysates, immunohistochemistry and immunofluorescence in fixed specimens, and ELISA-based quantification of receptor expression. Its polyclonal format provides broad epitope coverage across both extracellular and intracellular regions of the receptor, supporting detection in human samples.

Because SCTR drives pancreatic ductal bicarbonate and water secretion, modulates gastric acid release, contributes to hepatic bile flow, and participates in central nervous system signaling, this reagent is commonly incorporated into gastrointestinal physiology research, cardiac receptor pharmacology studies, and investigations of obesity-related metabolic pathways. Studies frequently rely on it to map receptor distribution in pancreatic, gastric, renal, and neural tissues, where SCTR expression patterns continue to be characterized.

For handling, the antibody should be refrigerated upon arrival and aliquoted to limit freeze-thaw cycles, and working dilutions can be prepared in buffer for routine immunolabeling. For paraffin-embedded tissue sections, citrate-based antigen retrieval is commonly used prior to immunohistochemistry, and the unconjugated format allows pairing with a secondary antibody compatible with the user's preferred detection chemistry. The reagent is supplied at a working concentration that researchers titrate empirically for each application.