Anti-SECISBP2 Antibody

Selenocysteine insertion sequence-binding protein 2 (SECISBP2) is the trans-acting factor that docks at SECIS elements in selenoprotein mRNA 3' untranslated regions, recruiting the elongation machinery that recodes internal UGA as selenocysteine. Loss-of-function mutations in this gene underlie SECISBP2 deficiency syndrome, a multi-system condition featuring abnormal thyroid hormone metabolism (elevated T4, reduced T3, normal or low TSH), photosensitivity, progressive muscular dystrophy-like myopathy, and male infertility arising from impaired spermatogenesis. Antibodies.com supplies a rabbit polyclonal Anti-SECISBP2 reagent for western blot, immunohistochemistry, and immunofluorescence detection of endogenous human SBP2.

The product is provided as 100 µl of unconjugated antibody at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, distributed as a single-use aliquot compatible with immediate dilution into blocking, staining, or hybridization buffers. The polyclonal host response delivers coverage of multiple epitopes on the SBP2 protein, which is relevant to downstream selenoproteins including glutathione peroxidases, thioredoxin reductases, and iodothyronine deiodinases probed across cell lysates, fixed tissue sections, and cultured cells. The reagent supports mapping of SBP2 expression patterns under physiological and pathological conditions, complementing studies of deiodinase regulation, glutathione peroxidase activity, and redox balance in the same biological samples.