Anti-Sec61 alpha-1 Antibody

The Sec61 translocon is the central protein-conducting channel of the endoplasmic reticulum, with the alpha-1 subunit forming the core pore through which nascent polypeptides enter the ER lumen or are integrated into the ER membrane. This unconjugated rabbit polyclonal antibody from Antibodies.com targets Sec61 alpha-1 and is validated for Western blot, immunohistochemistry, and immunofluorescence workflows using human samples. Supplied in a 100 µl vial, the polyclonal reagent offers recognition of multiple epitopes, an advantage when probing post-translational modifications or isoform variants of the translocon. The unconjugated format gives laboratories flexibility to pair it with HRP-, fluorophore-, or biotin-conjugated secondary reagents for detection. Researchers investigating co-translational protein targeting, ER stress responses, secretory pathway disorders, and ribosome-nascent chain complex dynamics routinely deploy anti-Sec61 alpha-1 reagents in immunoblotting and imaging experiments, where clear visualization of ER membrane architecture is essential.