Anti-SEC24C Antibody

Raised in rabbit, this unconjugated IgG polyclonal reagent from Antibodies.com specifically detects human SEC24C, a cargo-binding subunit of the COPII coat complex that mediates vesicle budding from the endoplasmic reticulum. SEC24C operates alongside paralogs SEC24A, SEC24B, and SEC24D at ER exit sites, where it cooperates with the inner coat component SEC23 and the small GTPase SAR1 to select transmembrane and lumenal cargoes for packaging into transport vesicles bound for the Golgi apparatus. The antibody is validated for Western blot detection of endogenous SEC24C in human cell and tissue lysates, supporting research into ER-to-Golgi trafficking, cargo sorting, and secretory pathway biogenesis. Supplied as a 100 µl volume, the reagent should be aliquoted upon receipt and stored at -20 °C; repeated freeze-thaw cycles should be avoided to maintain binding activity, with short-term handling of working dilutions at 4 °C.