Anti-SEC13 protein isoform 1 Antibody

This Rabbit polyclonal antibody from Antibodies.com targets SEC13 protein isoform 1, a core subunit of the COPII vesicle coat complex that mediates anterograde transport from the endoplasmic reticulum to the Golgi apparatus. SEC13 also functions as a structural component of the nuclear pore complex, contributing to nucleocytoplasmic trafficking. The unconjugated reagent is supplied as 100 µl of polyclonal antiserum raised in Rabbit, validated for western blot (WB) and immunohistochemistry (IHC) workflows on human samples.

SEC13 isoform 1 is broadly expressed across human tissues and assembles into a heterotetrameric coat with SEC31, SEC23, and SEC24, forming the outer cage that deforms ER membranes into transport carriers. Investigators studying ER-to-Golgi protein trafficking, vesicle biogenesis, and nuclear envelope architecture use this reagent to characterize expression patterns, monitor coat recruitment dynamics, and probe COPII assembly under varied experimental conditions. The unconjugated format allows flexible pairing with secondary antibodies and custom detection chemistries, and the polyclonal nature provides recognition of multiple epitopes on the target.