Anti-SDHB Antibody

This rabbit polyclonal reagent from Antibodies.com targets the iron-sulfur subunit B (SDHB) of mitochondrial succinate dehydrogenase, the TCA-cycle and respiratory-chain component routinely examined in metabolic and tumor-suppressor studies. Raised in rabbit and supplied as an unconjugated preparation in a 100 µl volume, it is validated for Western blot (WB) and immunofluorescence (IF) workflows on human samples, supporting research on oxidative phosphorylation, complex II assembly, and the HIF-pathway activation that follows SDHB loss.

Loss-of-function mutations and silencing of SDHB are linked to hereditary paraganglioma–pheochromocytoma syndromes, gastrointestinal stromal tumors, and renal cell carcinoma, so reliable detection of the protein is valuable for confirming expression status in patient-derived tissue and relevant cell-line models. The polyclonal format offers broader epitope coverage than a monoclonal clone, which is useful when probing fixed sections or denatured lysates where a single epitope may be compromised. Investigators studying mitochondrial dysfunction, pseudohypoxia signaling, or familial cancer syndromes will find this antibody a practical tool for both routine expression checks and more detailed subcellular localization studies.