Anti-SCN8A Antibody

SCN8A (Nav1.6) is a voltage-gated sodium channel alpha subunit predominantly expressed in the central nervous system. Mutations in the corresponding gene have been linked to developmental and epileptic encephalopathies, as well as peripheral motor and sensory hyperexcitability disorders, making the channel a long-standing focus of neuroscience and channelopathy research.

This rabbit polyclonal antibody from Antibodies.com targets SCN8A and is validated for Western blot detection in human, mouse, and rat sample lysates. The polyclonal format offers multi-epitope recognition across the Nav1.6 protein, which supports studies exploring full-length expression and modified channel variants in neuronal cell culture models, primary neuron preparations, and tissue homogenates.

Supplied unconjugated at 1 mg/ml in phosphate buffered saline with 15 mM sodium azide (approximate pH 7.2), the preparation is delivered as a 100 µl vial sufficient for several immunoblotting rounds. Keep refrigerated and protect from light; aliquot to limit freeze-thaw cycles if the reagent will be consumed over an extended period. For research use only.