Anti-SCD Antibody

Stearoyl-CoA Desaturase (SCD) is an integral membrane protein localized to the endoplasmic reticulum that catalyzes the rate-limiting step in monounsaturated fatty acid biosynthesis, converting saturated fatty acyl-CoA substrates into their monounsaturated forms. This rabbit polyclonal antibody from Antibodies.com targets SCD and is validated for Western blot detection of the endogenous protein in Human, Mouse, and Rat samples.

Supplied as 100 µl of unconjugated reagent at 1 mg/ml in phosphate buffered saline containing 15 mM sodium azide at approximately pH 7.2, the polyclonal format provides recognition of multiple epitopes on the target, which can be advantageous when probing isoforms or post-translationally modified variants. The unconjugated presentation allows the researcher to choose a secondary reporter such as HRP, a fluorophore, or biotin matched to the experimental read-out.

Sodium azide at 15 mM acts as a microbial preservative; aliquoting the stock upon first use and limiting repeated freeze-thaw cycles helps preserve antibody activity across the shelf life of the reagent. Researchers commonly apply this antibody to investigate SCD expression in metabolic disease models, including studies of hepatic lipogenesis, adipose tissue differentiation, and insulin-resistance phenotypes. Store refrigerated between uses and protect from light to maintain performance.