Anti-SCCA1 / 2 Antibody

Antibodies.com offers a polyclonal rabbit reagent that recognizes both SCCA1 (SERPINB3) and SCCA2 (SERPINB4), two squamous cell carcinoma antigen isoforms belonging to the ov-serpin clade of serine protease inhibitors. These serpins are overexpressed in cervical, head and neck, esophageal, and lung squamous carcinomas, and they are also elevated in benign hyperproliferative and inflammatory skin conditions such as psoriasis and atopic dermatitis. The antibody is supplied as a 100 µl unconjugated liquid aliquot, affinity-purified on protein A, and validated for Western blot and ELISA detection of the human target. It is intended for research use only and is suitable for in vitro studies of human SCCA isoforms. Storage at -20 °C in single-use aliquots preserves binding activity through multiple freeze-thaw cycles; the reagent should be kept on ice during working sessions and protected from light to prevent aggregation. Shipping is performed on cold packs to safeguard the cold chain during transit. Investigators studying serpin biology, HPV-driven cervical neoplasia, epithelial differentiation, or tumor biomarker discovery can deploy this reagent for expression profiling, mechanistic dissection of SERPINB3/B4 function, and quantitative immunoassay development.