Anti-SCARB2 Antibody

This unconjugated polyclonal reagent from Antibodies.com targets SCARB2 (also known as LIMP-2 and LGP85), a lysosomal and endosomal integral membrane protein best known for trafficking glucocerebrosidase from the endoplasmic reticulum to lysosomes. The antibody is raised in rabbit, is of the IgG isotype, and is supplied as a 50 µl aliquot suitable for repeated small-scale experiments.

Validated applications include Western blot for detection of SCARB2 in cell and tissue lysates, and immunohistochemistry for localization studies in fixed sections. The reagent has been verified to react with human, mouse, and rat samples, supporting cross-species work in models of lysosomal storage disorders and enterovirus entry research, where SCARB2 serves as the cellular receptor for EV71 and coxsackievirus A16.

Researchers studying Gaucher disease, action myoclonus-renal failure syndrome, or the cell biology of glucocerebrosidase trafficking will find this reagent useful for confirming expression levels, assessing lysosomal membrane integrity, and probing SCARB2-dependent viral uptake mechanisms. For handling, store refrigerated; for longer storage, aliquot and freeze to limit freeze-thaw cycles.