Anti-SBDS Antibody

Raised in rabbit against the SBDS ribosome maturation factor, this unconjugated polyclonal antibody from Antibodies.com is intended for researchers studying ribosome assembly and the molecular basis of Shwachman-Diamond syndrome. SBDS participates in late cytoplasmic maturation of the large ribosomal subunit, associates with the 60S particle, and is highly conserved across eukaryotes, making it a relevant target for groups working on bone marrow failure, pancreatic insufficiency, and skeletal phenotypes linked to SBDS loss-of-function.

Validated for Western blot and immunohistochemistry on human samples, the reagent is supplied as 100 µl of unconjugated antiserum. The polyclonal format allows recognition of multiple epitopes across the SBDS protein and can offer broader signal than a monoclonal reagent. For working use, aliquot upon receipt and store refrigerated; for longer-term storage, freeze and avoid repeated freeze-thaw cycles to preserve activity.

Provided as a liquid vial ready for dilution in standard assay buffers, the antibody fits standard cell lysate and tissue section workflows. Typical Western blot setups pair it with an anti-rabbit HRP secondary and chemiluminescent substrate, while IHC use is compatible with HRP- or biotin-streptavidin-based chromogenic detection. Manufacturer-confirmed reactivity is limited to human SBDS.