Anti-SATB1 Antibody

Special AT-rich sequence-binding protein 1 (SATB1) is a nuclear matrix-associated chromatin organizer that modulates gene expression by tethering AT-rich DNA elements to the nuclear scaffold, with documented roles in T-cell maturation, hematopoietic lineage commitment, and tumor invasion programs. The Antibodies.com polyclonal reagent was raised in rabbits and recognizes SATB1 in human, mouse, and rat samples, supporting cross-species comparative work in immunology and oncology laboratories.

Supplied as a 100 µl liquid at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the unconjugated format remains flexible for direct conjugation or pairing with secondary detection reagents. Validated applications include western blot analysis of cell lysates, immunohistochemistry on formalin-fixed tissue to map expression in thymus and lymphoid organs, and immunofluorescence imaging of nuclear compartmentalization.

Researchers characterizing regulatory T-cell populations, profiling chromatin remodeling events in breast cancer progression studies, or investigating pluripotent stem cell differentiation benefit from a polyclonal antibody that targets multiple epitopes of the SATB1 protein. Aliquoting upon arrival and storage at -20°C limits freeze-thaw cycles and preserves binding activity through repeated experiments.