Anti-SAMHD1 Antibody

For Western blot and immunohistochemistry workflows that probe innate immunity and nucleic-acid metabolism, this 100 µl polyclonal reagent from Antibodies.com detects the human SAM domain and HD domain-containing protein 1 (SAMHD1), a dNTP triphosphohydrolase that governs intracellular deoxynucleotide balance and restricts HIV-1 reverse transcription in non-dividing myeloid cells. The unconjugated rabbit host format provides flexibility for downstream labeling and custom detection chemistry.

SAMHD1 sits at the intersection of several active research areas. Loss-of-function mutations cause Aicardi-Goutières syndrome, an autoinflammatory encephalopathy, while altered expression has been documented in acute myeloid leukemia and related cancers where dNTP pool imbalance compromises DNA replication fidelity. Researchers studying viral restriction, autoimmunity, or oncogene-driven replication stress routinely monitor SAMHD1 abundance and phosphorylation status in patient-derived samples and relevant cell lines.

To preserve activity, aliquot upon first thaw to limit freeze-thaw cycles, then refrigerate for short-term use or store frozen at -20 °C for longer-term preservation. As a polyclonal reagent, the antibody recognizes multiple epitopes, which supports reliable detection in denatured Western blot samples and in fixed IHC tissue sections where single epitopes may otherwise be masked.