Anti-S100A12 Antibody

This rabbit polyclonal reagent from Antibodies.com targets S100A12, a calcium-binding EF-hand protein of the S100 family that is secreted abundantly by activated neutrophils and acts as a potent pro-inflammatory ligand for the receptor RAGE, also known as EN-RAGE. Supplied as 100 µL of unconjugated antiserum, the antibody is validated for western blot, immunohistochemistry, and immunofluorescence workflows on human samples, making it a practical tool for studies of innate immunity, chronic inflammatory disease, and neutrophil biology.

S100A12 is implicated in conditions such as rheumatoid arthritis, inflammatory bowel disease, vasculitis, and psoriasis, and is widely used as a serum biomarker of neutrophilic inflammation. Researchers therefore apply this reagent to map S100A12 expression in tissue sections and cultured cells, to follow its release in conditioned media, and to characterize neutrophil-rich infiltrates in disease models. As a polyclonal reagent raised in rabbit, it offers broad epitope coverage for detecting both the intracellular pool of S100A12 in granulocytes and the extracellular form that engages RAGE on endothelial and immune cells, supporting use in cell culture experiments, in vitro inflammation assays, and research use only applications.