Anti-RUNX2 Antibody

RUNX2 (Runt-related transcription factor 2) is a master regulator of osteoblast differentiation and skeletal development, and this polyclonal antibody from Antibodies.com offers a robust reagent for detecting endogenous RUNX2 protein in standard laboratory workflows. Raised in rabbit and supplied unconjugated at 100 µL, the antibody is validated for Western blot and ELISA applications and shows reactivity with human, mouse, and rat samples, supporting cross-species comparisons in bone biology, mesenchymal stem cell research, and oncology studies where RUNX2 dysregulation has been reported.

Because the reagent is polyclonal, it can recognize multiple epitopes on the target, which is useful when probing samples in which post-translational modifications, isoform switching, or partial proteolysis may alter antibody binding. Researchers studying chondrogenesis, dental tissue formation, osteosarcoma cell lines, or RUNX2-dependent signaling cascades can pair it with routine immunoblotting protocols to monitor protein-level changes across differentiation time courses, while ELISA compatibility allows quantitative readouts in cell lysates and tissue extracts. The unconjugated format also leaves the choice of secondary label and detection chemistry to the user, making it adaptable to chromogenic, fluorescent, or chemiluminescent detection pipelines.