Anti-RTN4 Antibody

This rabbit polyclonal reagent from Antibodies.com targets RTN4 (Reticulon-4, also known as Nogo), a membrane-associated protein best known for restricting neurite outgrowth and implicated in central nervous system injury responses, myelin biology, and neurodegenerative disease research. Raised in rabbit as an IgG polyclonal antibody, the unconjugated preparation is supplied at 100 µl and validated for Western blot (WB) and immunohistochemistry (IHC) workflows. Cross-reactivity has been confirmed against human, mouse, and rat samples, supporting translational studies in neural tissue, glial cell models, and spinal cord injury paradigms where the Nogo-A, Nogo-B, and Nogo-C isoforms are routinely examined. The polyclonal format increases the likelihood of recognizing multiple epitopes across the RTN4 protein, which is useful when probing full-length isoforms and processed fragments in lysates from cell culture and tissue sections. Store refrigerated, avoid repeated freeze-thaw cycles, and aliquot upon first use to preserve binding activity throughout the shelf life of the reagent.