Anti-RSK1 p90 Antibody

The RSK1 p90 ribosomal S6 kinase is a serine/threonine kinase operating downstream of the MAPK/ERK cascade, where it phosphorylates substrates involved in transcriptional regulation, cell-cycle progression, and survival signaling. This Rabbit polyclonal reagent from Antibodies.com targets the human RSK1 p90 protein and is supplied as 100 µl of unconjugated antiserum in a vial, allowing direct use in standard immunolabeling workflows without prior conjugation.

Validated applications include Western blot for detecting endogenous RSK1 expression across lysate preparations and immunofluorescence for visualizing subcellular localization in fixed cells. Being polyclonal, the reagent recognizes multiple epitopes on the target, increasing the likelihood of robust signal even when single epitopes are masked by fixation, denaturation, or post-translational modification.

Reactivity has been confirmed against human RSK1 p90, supporting studies of growth-factor-driven signaling, MAPK pathway activity, and oncology research where this kinase is frequently investigated. RSK1 p90 is studied as a downstream effector of Ras/Raf/MEK/ERK signaling and has been implicated in breast cancer and other solid tumors, making this antibody useful for signal-pathway interrogation and biomarker validation. Storage should follow standard antibody handling: refrigerate aliquots for short-term use, and freeze for long-term storage to limit freeze-thaw damage.