Anti-Rsk-1 (phospho-S380) Antibody

This polyclonal reagent from Antibodies.com targets the phosphorylated activation loop of p90 ribosomal S6 kinase 1 (Rsk-1) at serine 380, a site modified by ERK1/2 within the MAPK cascade. Supplied unconjugated at 1 mg/ml in phosphate buffered saline with 0.05% sodium azide at approximately pH 7.2, the antibody is intended for research applications that probe growth factor signaling, mitogenic responses, and downstream survival pathways.

Validated for Western blot and immunohistochemistry, the reagent produces reliable detection of the activated kinase in lysates and tissue sections. Cross-reactivity has been confirmed for human, mouse, and rat samples, enabling comparative work across common laboratory models. The polyclonal rabbit host format increases the likelihood of recognizing the phospho-S380 epitope even when nearby residues vary.

Each vial contains 100 µl of antibody for research use only, appropriate for studies on signal transduction, transcriptional regulation through CREB phosphorylation, and cellular stress responses where Rsk-1 activity contributes to downstream outcomes. Refrigerated storage preserves reagent integrity throughout the working shelf life.