Anti-RRM2 Antibody

This rabbit polyclonal antibody from Antibodies.com specifically recognizes the RRM2 subunit of ribonucleotide reductase, the small catalytic component responsible for converting ribonucleotides to deoxyribonucleotides during DNA synthesis and repair. Raised in rabbit and supplied as an unconjugated polyclonal reagent, it is validated for western blot (WB) and immunohistochemistry (IHC) workflows across human, mouse, and rat samples, supporting studies of cell proliferation, DNA replication, and tumor biology.

The target, RRM2 (Ribonucleoside-Diphosphate Reductase Subunit M2), is frequently overexpressed in many cancer types and has been investigated as a biomarker of gemcitabine resistance and proliferative capacity in tumor cells. Researchers studying DNA damage response, S-phase regulation, or chemoresistance mechanisms can apply this antibody to lysates and tissue sections to track endogenous RRM2 levels. The reagent is provided at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a 100 µl vial, suitable for storage at -20°C with minimal freeze-thaw cycling to preserve activity.