Anti-RRAGC Antibody

RagC is the GDP-bound half of the heterodimeric Rag GTPase pair that anchors mTORC1 to the lysosomal surface, where it cooperates with RagA or RagB to convert intracellular amino acid availability into a growth-promoting signal. This rabbit polyclonal reagent from Antibodies.com was raised against a synthetic peptide derived from human RRAGC and purified by antigen affinity chromatography before being supplied as an unconjugated IgG in a 100 µl liquid format. The antibody has been validated for western blot, immunohistochemistry, and immunofluorescence and cross-reacts with samples from human, mouse, and rat, supporting comparative work in cell culture models and tissue sections. The reagent is widely used to monitor Rag complex assembly and amino acid starvation and re-feeding responses in experiments that pair it with mTORC1 readouts such as phospho-S6K1 or 4E-BP1. The unconjugated format lets researchers couple the antibody to HRP, biotin, or a fluorophore of their choice for custom detection chemistries. For long-term stability, aliquot on receipt and store at -20 °C to limit freeze-thaw cycles and preserve binding activity across experiments. For research use only.