Anti-RPS6KB1 (phospho S424) Antibody

This rabbit polyclonal IgG antibody from Antibodies.com is raised against ribosomal protein S6 kinase beta-1 (RPS6KB1), also known as p70 S6 kinase, and selectively recognizes the phosphorylated serine 424 residue within the kinase's C-terminal regulatory region. Phosphorylation at this site contributes to kinase activation downstream of mTORC1 signaling, making the reagent a useful reagent for studying translational control, insulin-stimulated signaling, and growth-factor-driven cell growth in cultured cells and tissue sections.

Validated for western blot, immunohistochemistry, and immunofluorescence workflows, the unconjugated antibody is supplied as a 100 µl liquid aliquot and is reactive with human, mouse, and rat samples, supporting cross-species studies of S6K pathway activity in models of metabolism, cancer, and aging research. Aliquot handling and short-term refrigerated storage preserve phospho-specific recognition for repeated use in blotting and imaging assays.