Anti-RPS6KB1 (phospho S411) Antibody

This phospho-specific polyclonal antibody from Antibodies.com selectively recognizes ribosomal protein S6 kinase B1 (RPS6KB1, also known as p70S6K or S6K1) when phosphorylated at serine 411, an autophosphorylation site commonly tracked as a read-out of mTOR pathway activation in cell signaling research.

The reagent is raised in rabbit (IgG isotype) and supplied unconjugated in a 50 µl single-use format. It supports western blot, immunohistochemistry, and immunofluorescence workflows, with reactivity validated against human, mouse, and rat samples to enable translational studies of cell growth, protein synthesis, and metabolic regulation.

Phospho-S411 levels on RPS6KB1 rise in response to mitogens, amino acids, and cellular stress that engage mTORC1, making this reagent a useful marker of pathway activity alongside total p70S6K and downstream ribosomal S6 readouts. For best results, store refrigerated in working aliquots, protect from light, and avoid repeated freeze-thaw cycles to preserve phospho-epitope recognition. Intended for research use only.