Anti-RPS6KB1 Antibody

Polyclonal antibody for RPS6KB1 (ribosomal protein S6 kinase B1, also known as p70 S6 kinase or S6K1) is raised in rabbit and validated for western blot, immunohistochemistry, and immunoprecipitation. The target sits downstream of mTORC1 and phosphorylates ribosomal protein S6 to drive translational control linked to cell growth, proliferation, and metabolic regulation, making it broadly useful across cancer biology, insulin signaling, and metabolic-disease research. Supplied as 50 µl of unconjugated antisera, the reagent recognizes endogenous human, mouse, and rat RPS6KB1 and supports IP-based complex pull-down alongside IHC staining on formalin-fixed tissue sections. Investigators tracking PI3K/AKT/mTOR pathway activity, insulin signaling, or oncogenic translation control routinely pair this Antibodies.com reagent with phospho-specific antibodies to compare activation state versus total protein across cell and animal models, and the polyclonal format allows recognition of multiple epitopes for robust detection of the p70 and p85 isoforms.