Anti-RPS4Y1 Antibody

Ribosomal protein S4 Y-linked 1 (RPS4Y1) is a Y-chromosome-encoded component of the 40S ribosomal subunit, expressed in male cells because the gene has no functional X-linked counterpart. This unconjugated polyclonal reagent from Antibodies.com was raised in rabbit and is supplied as 100 µl of liquid stock. It is validated for Western blot and immunofluorescence on human samples, supporting routine confirmation of sex-chromosome complement in cell lines, primary cultures, and tissue sections used in basic research workflows.

Beyond standard expression profiling, the antibody is widely used in forensic science and ancient DNA studies to assign biological sex from limited material, and in developmental biology where male and female reference samples need to be distinguished at the protein level rather than by DNA genotyping. Because RPS4Y1 maps to the male-specific region of the Y (MSY), immunostaining also helps track engineered Y-chromosome deletions and characterize sex-chromosome aneuploidy models.