Anti-RPS14 Antibody

RPS14 (ribosomal protein S14) is a highly conserved constituent of the small 40S ribosomal subunit, making this polyclonal reagent from Antibodies.com a useful tool for translational and ribosome-biogenesis research. Raised in rabbit and purified as an IgG preparation, the unconjugated antibody recognizes human RPS14 and is validated for Western blot applications, where a band near the expected molecular weight of roughly 16 kDa is typically observed on standard SDS-PAGE gels.

RPS14 expression is frequently studied in the context of Diamond-Blackfan anemia and the del(5q) subset of myelodysplastic syndrome, where haploinsufficiency driven by loss of a single allele activates a p53-dependent ribotoxic stress response that blocks erythroid progenitor maturation. Researchers also use anti-RPS14 antibodies to probe translation capacity in cancer cell lines, stress-granule dynamics, and ribosomal assembly defects under conditions of cellular stress or nucleolar disruption.

The antibody is supplied from Antibodies.com as a 200 µL liquid aliquot in a single-use vial format and should be stored refrigerated; aliquoting on first use helps preserve activity across multiple experiments. For Western blot, the reagent is commonly applied to whole-cell lysates, with detection carried out via secondary antibodies and detection chemistry chosen by the end user.

For research use only. Not intended for diagnostic or therapeutic applications.