Anti-Rock-2 Antibody

Rho-associated coiled-coil containing kinase 2 (Rock-2) is a serine/threonine kinase that acts as a downstream effector of RhoA GTPase, regulating actin cytoskeleton dynamics, stress fiber formation, focal adhesion assembly, and smooth muscle contraction. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against the Rock2 target and is supplied at 100 µl, supporting reproducible detection across immunoblotting and ELISA workflows.

Validated reactivity spans human, mouse, rat, and monkey samples, making the antibody useful for comparative studies of ROCK signaling in cardiovascular, neuronal, and fibrotic disease models. Western blot analysis reveals a band consistent with the ~160 kDa Rock-2 protein in lysates from cultured mammalian cells and relevant tissues.

Each lot is supplied as a liquid polyclonal antiserum fraction in a vial suitable for long-term storage according to the manufacturer's recommendations. Researchers commonly dilute the antibody for routine immunoblotting and employ it as a probe to investigate phosphorylation-dependent regulation of myosin light chain, vimentin, and other Rock-2 substrates.