Anti-ROCK-1 Antibody

This recombinant rabbit monoclonal antibody specifically targets ROCK-1 (Rho-associated coiled-coil-containing protein kinase 1), a ~158 kDa serine/threonine kinase that acts as a downstream effector of RhoA GTPase signalling. From Antibodies.com, the unconjugated reagent is supplied as 50 µl in a TBS (pH 7.4) buffer containing 1% BSA, 40% glycerol, and 0.05% sodium azide as preservative.

ROCK-1 regulates actin cytoskeleton dynamics, stress fibre and focal adhesion formation, cell migration, and smooth muscle contraction. Researchers apply this antibody across western blot, immunocytochemistry/immunofluorescence, immunohistochemistry, and flow cytometry workflows to probe ROCK-1 expression in Human, Mouse, and Rat samples, supporting studies in cardiovascular biology, cancer cell motility, neurodegeneration, and fibrosis research. The recombinant monoclonal format delivers consistent specificity for reproducible detection in cell lysates and tissue sections.

For handling, aliquot upon first use to limit repeated freeze-thaw cycles on the stock vial, and protect from light during extended storage. The 40% glycerol and 1% BSA stabilisers preserve antibody activity, while the 0.05% sodium azide prevents microbial contamination during bench-top use in staining and labelling protocols.