Anti-ROCK-1 Antibody

Recombinant rabbit monoclonal antibody targeting ROCK-1 (Rho-associated coiled-coil kinase 1), supplied by Antibodies.com as a 100 µl vial of unconjugated primary antibody. The clone is raised in rabbit hosts and purified in a TBS buffer (pH 7.4) supplemented with 1% BSA and 40% glycerol, with 0.05% sodium azide added as a preservative.

Validated for multiple immunodetection techniques, the reagent supports western blot analysis of ROCK-1 expression in cell lysates, immunocytochemistry and immunofluorescence imaging of cytoskeletal localization, immunohistochemistry on tissue sections, and flow cytometry workflows. Cross-reactivity is confirmed against human, mouse, and rat samples, enabling comparative studies across standard model systems used in cell biology and disease research.

ROCK-1 is a serine/threonine kinase that acts downstream of RhoA GTPase to regulate actin-myosin contractility, stress fiber formation, focal adhesion turnover, and cell motility. Investigators apply this antibody to study cytoskeletal remodeling, smooth muscle contraction, cell migration, neurite outgrowth, and the role of ROCK signaling in cancer invasion, fibrosis, and vascular pathophysiology.