Anti-RNF40 Antibody

This unconjugated rabbit polyclonal antibody specifically targets RNF40, also called BRE1A, a nuclear E3 ubiquitin ligase that functions as part of the RNF20/40 heterodimer complex. Working together with RNF20, RNF40 monoubiquitinates histone H2B at lysine 120, a chromatin modification linked to active transcription elongation, the DNA damage response, and stem cell maintenance.

Validated for western blot and immunofluorescence workflows, the reagent allows researchers to probe endogenous RNF40 expression across human, mouse, and rat samples. The polyclonal format offers recognition of multiple epitopes on the target, which is helpful when studying post-translational regulation, chromatin-associated complexes, or co-immunoprecipitation experiments involving histone-modifying machinery.

Provided by Antibodies.com as a 100 µl vial of liquid antibody, this product ships ready to dilute for standard immunodetection protocols. Aliquot on arrival and store at -20°C in single-use portions to preserve activity across multiple freeze-thaw cycles; protect from light and avoid prolonged exposure to room temperature. Intended for research use only.