Anti-RNF40 Antibody

RNF40 (RING finger protein 40), also referred to as BRE1B, functions as an E3 ubiquitin ligase that pairs with its heterodimer partner RNF20 to monoubiquitinate histone H2B at lysine 120. This H2BK120ub1 mark is required for productive transcriptional elongation, proper DNA damage signaling, and maintenance of chromatin structure, with documented roles in stem cell self-renewal, cell cycle progression, and tumor suppressor regulation. This rabbit polyclonal antibody from Antibodies.com is raised against human RNF40 and supplied as an unconjugated, 100 µl aliquot validated for western blot and immunohistochemistry on human samples. The reagent supports investigations into epigenetic regulation of gene expression, ubiquitin pathway biology, and chromatin-associated signaling in cancer and developmental biology contexts.