Anti-RNF2 Antibody

This polyclonal rabbit IgG antibody from Antibodies.com targets RNF2 (Ring Finger Protein 2), also referred to as RING1B. RNF2 acts as the catalytic E3 ubiquitin ligase subunit of Polycomb Repressive Complex 1 and deposits monoubiquitin marks on histone H2A at lysine 119, a modification associated with chromatin compaction and transcriptional silencing of developmental loci.

Supplied as a 100 µl unconjugated liquid aliquot, the reagent is validated for Western blot detection of endogenous human RNF2, with the target protein migrating at approximately 38 kDa. Investigators in epigenetics, stem cell biology, and cancer research use this antibody to characterise PRC1-mediated gene repression, examine X-inactivation status, and survey H2AK119ub levels in tumour-derived samples. The polyclonal rabbit host provides recognition of multiple epitopes, supporting consistent detection across a panel of human cell lines and primary cultures.

For routine handling, aliquot on first thaw and store at -20 °C in a frost-free freezer; avoid repeated freeze-thaw cycles to preserve binding activity. The product is intended for research use only and is not approved for diagnostic or therapeutic applications.