Anti-RNF126 Antibody

RNF126 is a RING-finger family E3 ubiquitin ligase that attaches ubiquitin chains to substrate proteins, directing them toward proteasomal turnover and contributing to cellular protein quality control. This unconjugated rabbit polyclonal reagent is supplied by Antibodies.com as a 50 µl aliquot and is validated for western blot and immunohistochemistry workflows on human, mouse, and rat samples. The antibody binds the full-length RNF126 protein and supports research into ER-associated degradation (ERAD), the DNA damage response, and signaling pathways in which RNF126-mediated ubiquitination has been implicated, including EGFR turnover and cancer cell proliferation. As an IgG isotype preparation raised in rabbit, it can be paired with common anti-rabbit HRP or fluorescent secondary reagents for chemiluminescent western blot films or chromogenic IHC sections.