Anti-RNA-binding protein FUS Antibody

This unconjugated rabbit polyclonal antibody from Antibodies.com targets RNA-binding protein FUS (Fused in Sarcoma), a multifunctional nuclear protein involved in transcription regulation, pre-mRNA splicing, and the DNA damage response. The reagent is validated for Western blot and immunohistochemistry workflows and shows reactivity against human FUS, supporting laboratories researching neurodegeneration, ALS and FTLD pathology, and the translocation biology underlying certain sarcomas.

Supplied at 100 µg, the polyclonal antibody is unconjugated, allowing laboratories to pair it with secondary reagents of their choice. FUS migrates near 53 kDa on SDS-PAGE, and researchers commonly use Western blot to detect full-length FUS alongside truncated or aggregation-prone species generated in disease models. In immunohistochemistry, the antibody highlights nuclear staining in normal cells and reveals cytoplasmic mislocalization in affected motor neurons, a hallmark of FUS-proteinopathy studies.

Recommended storage at -20°C in working aliquots helps preserve antibody activity across multiple freeze-thaw cycles. This reagent fits research use only applications in cell and tissue biology, neuroscience, and oncology laboratories.