Anti-RIPK3 Antibody

This polyclonal antibody targets receptor-interacting serine/threonine protein kinase 3 (RIPK3), a key mediator of necroptotic cell death signaling. Produced in rabbits and supplied at 1 mg/ml in phosphate buffered saline containing 15 mM sodium azide at approximately pH 7.2, the unconjugated reagent is delivered as a 100 µl aliquot for Western blot workflows using human, mouse, and rat samples.

RIPK3 plays a central role in programmed necrosis through phosphorylation of MLKL following death receptor activation. Researchers studying TNF-driven inflammatory pathways, necroptosis mechanisms, and innate immune signaling use anti-RIPK3 antibodies to confirm pathway engagement and assess downstream effector activation. The polyclonal format offers epitope diversity, useful when detecting a broader range of RIPK3 isoforms and post-translational modifications.

Aliquots should be handled according to Antibodies.com guidance to preserve activity, and repeat freeze-thaw cycles should be avoided to maintain reagent integrity.