Anti-RHEB Antibody

This polyclonal antibody from Antibodies.com targets RHEB (Ras homolog enriched in brain), a small GTPase that sits upstream of mTOR complex 1 and regulates growth signaling, autophagy, and protein synthesis. Researchers use it in western blot and immunohistochemistry workflows to probe RHEB expression across Human, Mouse, and Rat samples.

The reagent is raised in Rabbit and supplied as 100 µl of unconjugated antiserum, ready for HRP- or fluorophore-conjugated secondary detection depending on the assay design. The polyclonal format broadens epitope coverage on RHEB, which is useful when evaluating post-translational modifications or alternative splice variants.

Common research applications include mapping the TSC1/TSC2-RHEB-mTOR axis in cancer cell lines, profiling RHEB in neuronal tissue sections, and characterizing metabolic disease models. Cross-reactivity with the rodent orthologs makes the antibody practical for side-by-side comparative studies across species.

For handling, aliquot upon receipt and freeze for long-term storage; avoid repeated freeze-thaw cycles to preserve activity.