Anti-RGS7 Antibody

RGS7 belongs to the Regulator of G-protein Signaling family of GTPase-activating proteins that accelerate GTP hydrolysis on heterotrimeric G-protein α subunits, modulating downstream cascades initiated by G-protein coupled receptors. The polyclonal reagent distributed by Antibodies.com is raised in rabbit and supplied as an unconjugated IgG at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, packaged in a 100 µl vial. The antibody is validated for Western blot and immunohistochemistry and was raised against a target conserved in human, mouse, and rat samples, enabling comparative work across species. RGS7 forms an obligate heterodimer with the Gβ5 subunit and binds scaffold partners such as R7BP and R9AP, positioning it at the interface between GPCR activation and effector regulation in neurons, retinal photoreceptors, and cardiac pacemaker cells. Investigators studying opioid analgesia, phototransduction, bradycardia, or striatal dopaminergic signaling commonly apply this reagent to detect endogenous RGS7 in brain, spinal cord, retina, and heart lysates by WB, and to localize the protein in formalin-fixed paraffin-embedded sections by IHC. Aliquot upon first thaw, store refrigerated, protect from light, and limit freeze-thaw cycles to preserve antibody activity. For research use only.