Anti-RGS5 Antibody

RGS5 is a member of the regulator of G-protein signaling family that acts as a GTPase-activating protein, accelerating the deactivation of heterotrimeric G-protein α subunits and terminating downstream G-protein-coupled receptor signaling. This rabbit polyclonal antibody from Antibodies.com is supplied as an unconjugated 100 µl aliquot and has been validated for Western blot and immunohistochemistry on human and mouse samples.

RGS5 expression is concentrated in pericytes and vascular smooth muscle cells, where it influences blood vessel maturation, angiogenic remodeling, and vascular tone regulation. In tumor biology, RGS5 serves as a marker for pericytes that interact with endothelial cells, supporting studies of aberrant angiogenesis, vessel normalization under antiangiogenic therapy, and stromal crosstalk within the tumor microenvironment. Cardiac, renal, and fibrotic disease models also rely on RGS5 detection to track pericyte behavior during tissue remodeling after ischemic injury.

For Western blot, the polyclonal format provides broad epitope coverage of endogenous RGS5 in cell lysates and tissue homogenates. Immunohistochemistry on formalin-fixed paraffin-embedded sections produces cytoplasmic and perivascular staining that highlights pericyte ensheathment of capillaries. Store refrigerated and protect from light to preserve reagent stability; aliquot upon first use and minimize freeze-thaw cycles to extend functional lifetime across ongoing research projects.