Anti-RGS3 Antibody

Raised in rabbit hosts, this polyclonal IgG reagent from Antibodies.com targets Regulator of G-protein Signaling 3 (RGS3), a GTPase-activating protein that accelerates GTP hydrolysis on heterotrimeric Gα subunits and modulates downstream GPCR signaling cascades.

Validated for Western blot (WB) work, the unconjugated primary antibody recognizes human RGS3 and is supplied as 100 µl of liquid. RGS3 expression has been characterized in studies of cell migration, apoptosis regulation, and cancer biology contexts such as ovarian and gastric carcinomas, where altered RGS3 levels have been associated with tumor cell behavior and signal termination kinetics.

Investigators studying GPCR signal desensitization or RGS family expression can apply this reagent to detect endogenous human RGS3 in whole-cell lysates and tissue homogenates separated under denaturing SDS-PAGE conditions. The polyclonal format offers broader epitope coverage than monoclonal alternatives, supporting recognition of multiple RGS3 splice variants.