Anti-RGS14 Antibody

This unconjugated rabbit polyclonal antibody specifically targets Regulator of G-protein Signaling 14 (RGS14), a multifunctional scaffolding protein expressed predominantly in hippocampal CA2 pyramidal neurons, where it modulates Gαi/o signaling, suppresses synaptic plasticity, and participates in mitotic spindle regulation. Raised in rabbit and supplied at 100 µl by Antibodies.com, the reagent is validated for Western blot (WB) and immunohistochemistry (IHC) on human samples, supporting research in neurobiology, G-protein coupled receptor signaling, and oncology, where altered RGS14 expression has been reported in breast and lung tumor tissues.

Provided as a polyclonal antiserum without fluorophore or enzyme conjugation, the antibody offers flexibility for downstream detection chemistries, including HRP-, biotin-, or fluorescent-secondary based systems. Storage at -20 °C in working aliquots is recommended to limit freeze-thaw cycles and preserve binding activity over the product's shelf life. Researchers investigating G-protein regulation, CA2-dependent social and spatial memory, estrous-cycle linked plasticity, or the contribution of RGS14 to cell cycle progression and tumor biology can integrate this reagent into established WB and IHC workflows.