Anti-RGS1 Antibody

Targeting Regulator of G-protein Signaling 1 (RGS1), this polyclonal antibody from Antibodies.com is raised in rabbit hosts and supplied as a 100 µl unconjugated reagent validated for western blot and immunohistochemistry workflows. RGS1 is a GTPase-activating protein that attenuates Gα signaling downstream of chemokine receptors, playing critical roles in B-cell receptor signaling, lymphocyte homing to secondary lymphoid organs, and germinal center B-cell function.

The reagent cross-reacts with both human and mouse RGS1, supporting comparative studies in cell line panels and rodent tissue models. In western blot applications, the antibody enables detection of endogenous RGS1 expression in lymphoid cell lines and primary immune cells, while immunohistochemistry use allows visualization of RGS1 distribution in tissue sections, including lymph node, spleen, and tonsil specimens where RGS1 is characteristically expressed by activated B lymphocytes.

Produced as a polyclonal reagent, the antibody recognizes multiple epitopes across the RGS1 protein, providing broader target coverage than monoclonal alternatives. The unconjugated format allows researchers to pair the primary antibody with their preferred detection system, including HRP-conjugated secondary antibodies for chromogenic western blot and IHC, or fluorophore-conjugated secondaries for immunofluorescence workflows.

Researchers investigating B-cell lymphoma biology, germinal center formation, chemokine receptor signaling, and immune cell migration will find this reagent applicable to studies examining RGS1-mediated regulation of G-protein-coupled receptor pathways. For handling, store refrigerated and protect from light; aliquot the reagent upon arrival to limit freeze-thaw cycles and preserve antibody activity across multiple experiments.