Anti-RGR Antibody

The RGR target (Retinal G Protein-Coupled Receptor) is a rhodopsin-class GPCR localized to the retinal pigment epithelium and Müller glial cells, where it participates in the retinoid visual cycle by binding all-trans-retinal. Antibodies.com supplies this polyclonal, unconjugated reagent raised in rabbit for western blot, immunohistochemistry, and flow cytometry on human samples.

Each vial ships with 200 µl of antibody, formatted for routine lab use with an IgG isotype backbone that supports broad secondary antibody compatibility. Researchers studying retinitis pigmentosa, age-related macular degeneration, and other inherited retinal dystrophies use this reagent to probe RGR expression in tissue sections and cell lysates.

The unconjugated status allows downstream labeling with fluorophores, biotin, or enzymes depending on the detection platform. For best results, refrigerate upon arrival and protect from light; minimize freeze-thaw cycles to maintain titer across multiple experiments.

Investigations into RGR mutations linked to autosomal recessive retinitis pigmentosa and choroidal sclerosis have relied on RGR-specific antibodies to confirm loss-of-function phenotypes in patient-derived iPSC-RPE models and to validate gene therapy rescue strategies in preclinical studies.