Anti-RFWD3 Antibody

RFWD3 (RING finger and WD repeat domain 3) is a DNA damage-response E3 ubiquitin ligase that plays a critical role in the Fanconi anemia pathway and replication fork protection. This unconjugated rabbit polyclonal antibody from Antibodies.com is raised against human RFWD3 and is supplied as 100 µl of polyclonal antiserum for use in Western blot, immunohistochemistry, and ELISA workflows across research studying genome stability, homologous recombination, and BRCA-associated repair mechanisms.

The antibody detects endogenous human RFWD3 expression in human samples and is validated for multiple research applications. Investigators studying RPA-mediated ubiquitination, PCNA interactions at stalled forks, or chemoresistance pathways in BRCA-deficient tumor models commonly use this reagent to profile RFWD3 levels in cell lines and tissue sections. Because RFWD3 has been linked to hereditary cancer syndromes and replication stress signaling, the antibody supports studies connecting E3 ligase activity to checkpoint activation, fork restart, and DNA repair fidelity.