Anti-RFFL Antibody

The RFFL target (Ring Finger and FYVE-like Domain Containing E3 Ubiquitin Protein Ligase), also referred to as Rififylin, is a membrane-anchored E3 ubiquitin ligase that participates in Caspase-8-mediated apoptotic signaling and in the endosomal sorting of activated receptors. This rabbit polyclonal IgG reagent from Antibodies.com was raised against the human RFFL protein and is validated for Western blot detection in lysates from human, mouse, and rat samples. Supplied as an unconjugated 100 µl liquid aliquot, the antibody supports multiple blotting experiments from a single vial; refrigerate upon arrival and aliquot to limit freeze-thaw cycles for longer-term use. Researchers apply this reagent to characterize RFFL-dependent ubiquitination events, to study TNF-family death receptor pathways, and to probe receptor tyrosine kinase trafficking through early endosomes.