Anti-REN Antibody

This rabbit polyclonal antibody from Antibodies.com targets renin (REN), the aspartyl protease secreted by juxtaglomerular cells of the kidney that initiates the renin-angiotensin-aldosterone system. By cleaving angiotensinogen to generate angiotensin I, renin sits at the top of a hormonal cascade governing blood pressure, sodium retention, and vascular tone, which is why anti-REN reagents are widely used in cardiovascular, renal, and metabolic disease research.

Supplied as 100 µl of unconjugated polyclonal antiserum raised in rabbit, the antibody is validated for Western blot (WB) and immunohistochemistry (IHC) on human samples. Investigators apply it to map renin expression in kidney sections, profile RAAS activity in hypertensive or diabetic models, and confirm ectopic hormone production in tumor or tissue panels where renin-secreting cells are of interest.

Because the reagent is unconjugated, it pairs cleanly with secondary antibodies of the researcher's choice, supporting flexible chromogenic or fluorescence detection workflows in IHC and immunoblotting. The polyclonal format increases the likelihood of recognizing multiple epitopes on the renin precursor and mature forms, which is useful when probing cleavage products or comparing isoform expression across tissues.