Anti-Ref-1 Antibody

This polyclonal antibody from Antibodies.com targets Ref-1 (also known as APE1 or APEX1), a multifunctional protein that operates as both a key apurinic/apyrimidinic endonuclease in the base excision DNA repair pathway and a redox co-activator of transcription factors such as NF-κB, AP-1, and HIF-1α. Raised in rabbit and supplied unconjugated at 100 µl, the reagent supports Western blot, immunohistochemistry, and ELISA workflows on human, mouse, and rat samples. Investigators apply it to studies of oxidative stress signaling, tumor progression, and neurodegeneration, where monitoring Ref-1 expression and its nuclear versus cytoplasmic distribution yields biologically meaningful readouts. The polyclonal composition enables recognition of multiple epitopes on the ~37 kDa target, providing reliable signal in denatured lysates and in fixed tissue sections typical of these assays.