Anti-RBBP5 Antibody

Primary antibody targeting RBBP5 (Retinoblastoma-Binding Protein 5), a core scaffold subunit of MLL and COMPASS-like histone H3K4 methyltransferase complexes. Raised in rabbit and supplied as an unconjugated IgG polyclonal reagent in a 200 µl vial, this product from Antibodies.com has been validated for western blot, immunohistochemistry, and immunofluorescence detection on human, mouse, and rat samples.

RBBP5 forms the WRAD module together with WDR5, ASH2L, and DPY30, anchoring catalytic MLL/SET1 family enzymes that deposit activating H3K4 methylation marks on chromatin. Investigators working on epigenetic regulation of transcription, MLL-rearranged leukemia, hematopoiesis, embryonic stem cell self-renewal, and developmental gene activation use this reagent to monitor complex assembly and chromatin modification dynamics in cell culture and tissue preparations.

The unconjugated polyclonal format offers flexibility to conjugate fluorophores, horseradish peroxidase, alkaline phosphatase, or biotin depending on the downstream detection chemistry required, extending utility beyond the validated applications into immunoprecipitation-based enrichment workflows.