Anti-RBBP4 Antibody

Produced in rabbit and supplied by Antibodies.com as an unconjugated polyclonal antiserum, this reagent targets the retinoblastoma-binding protein RBBP4 (also known as RbAp48), a ~48 kDa WD40-repeat histone chaperone that deposits newly synthesized H3.1/H4 dimers onto replicating DNA as part of the CAF-1 complex and serves as a core subunit of the NuRD, PRC2, and Hat1 chromatin-modifying assemblies.

The antibody is validated for Western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, and chromatin immunoprecipitation workflows, and it cross-reacts with endogenous RBBP4 orthologs in human, mouse, and rat samples, supporting comparative chromatin biology studies across mammalian model systems.

The 100 µl liquid aliquot is supplied in a storage buffer suited to refrigerated handling; aliquot on first use to limit freeze-thaw cycles. Researchers apply this reagent for ChIP-seq target validation, mapping RBBP4 occupancy at replication origins and Polycomb target genes, or probing the assembly state of CAF-1 and NuRD complexes in nuclear extracts.